A 52-Week Study of Dose Adjusted Subcutaneous Testosterone Enanthate
in Oil Self-Administered Via Disposable Auto-Injector

# A 52-Week Study of Dose Adjusted Subcutaneous Testosterone Enanthate
in Oil Self-Administered via Disposable Auto-Injector

## Abstract
This study investigates the efficacy and safety of subcutaneously administered
testosterone enanthate (TE) in oil form, self-injected using a disposable auto-injector over 52 weeks.
The primary goal was to assess whether dose adjustments could optimize therapeutic outcomes while maintaining patient convenience and adherence.
Data were collected from 100 participants enrolled in a
prospective, observational study. Results indicated that the subcutaneous TE in oil formulation demonstrated consistent efficacy, with serum testosterone levels
remaining within the therapeutic range throughout the study period.
Adverse events were mild and comparable to those typically associated with subcutaneous testosterone administration. This study provides evidence supporting the safety and practicality of
self-administration of TE in oil via auto-injector for long-term management of hypogonadism.

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## Authors
John Doe, MD
Jane Smith, PhD

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## Affiliations
Department of Endocrinology, University Hospital, Cityville, Countryname

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## Methods
This prospective, observational study enrolled 100 adult males (ages 18-65) diagnosed with hypogonadism.
Participants received subcutaneous TE in oil via a disposable auto-injector at doses adjusted according to individualized
protocols based on blood testosterone levels and clinical response.
Study duration was 52 weeks, with adherence assessed through
injection logs and follow-up visits. Efficacy was measured via serum testosterone, hemoglobin, and adverse event reporting.

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## Results
Over the course of the study, 95% of participants reported consistent adherence to their
injection regimen. Serum testosterone levels remained within the therapeutic range
(4-12 ng/mL) for all participants, with no significant differences observed between dose adjustment
groups. The incidence of adverse events was low, primarily consisting
of localized pain or erythema at injection sites. No serious infections or other complications
were reported.

Notably, a correlation was observed between dose and efficacy, with higher doses associated with
improved symptoms of hypogonadism (e.g., increased energy,
enhanced libido). However, no evidence of tolerance or rebound hypogonadism was noted
during the study period.

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## Discussion
The findings suggest that subcutaneous TE in oil is a safe and effective alternative for testosterone replacement therapy, particularly for patients who prefer self-administration. The convenience of using a disposable auto-injector may improve adherence rates
compared to traditional vial administration methods.
However, further studies are needed to confirm these
results in larger, diverse populations and to assess
long-term outcomes beyond the 52-week study period.

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## Keywords
Testosterone enanthate, subcutaneous injection, hypogonadism, auto-injector, adherence

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